Saturday, July 19, 2025

Genetic Constants In DNA and RNA - 7

Fig. 1 The Law Applies To RNA

Chargaff's Rule can easily be applied to RNA (see the mRNA example in the video below).

In this series what has been and still is being explored is genetic rules or constants related to DNA and RNA sequences.

This is not the first time in history such tests have been suggested for DNA, but it might be the first for the RNA hypothesis:

In the RNA of any species and any organism, the amount of guanine ['G'] should be equal to the amount of cytosine ['C'] and the amount of adenine ['A'] should be equal to the amount of uracil ['U'].

(See Fig. 2 and Genetic Constants In DNA and RNA - 6). In like manner, in several Dredd Blog series we have delved into the constants of atoms in DNA and RNA genomes:

On The Origin Of A Genetic Constant, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14. 15

It's In The GenBank, 2, 3, 4, 5, 6, 7, 8, 9

The point of it all in one sense is that with this in mind a DNA or RNA sequence can be tested quite easily for accuracy.

Fig. 2 The Law Applies To DNA
These tests should primarily be utilized by researchers and scientists prior to submitting them to public databases such as GenBank:

"You've read or heard the phrase "don't blame the victim" I suppose.

So, let's not blame GenBank for what researchers put in it ..."

(It's In The GenBank - 9). So, keep that in mind when considering (Ten common issues with reference sequence databases and how to mitigate them).

The previous post in this series is here.


Notice carefully that the relevant thymine ('T') becomes converted into an equal number of relevant uracil ('U') components during the DNA->mRNA phase:


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