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| Fig. 1 Chargaff's Rule |
In this series what has been and still is being explored is genetic rules or constants related to DNA and RNA sequences.
This is not the first time in history such tests have been suggested:
"Chargaff's rules (given by Erwin Chargaff) state that in the DNA of any species and any organism, the amount of guanine ['G'] should be equal to the amount of cytosine ['C'] and the amount of adenine ['A'] should be equal to the amount of thymine ['T']. Further, a 1:1 stoichiometric ratio of purine and pyrimidine bases (i.e., A+G=T+C) should exist. This pattern is found in both strands of the DNA. They were discovered by Austrian-born chemist Erwin Chargaff in the late 1940s."
(Wikipedia; cf Chargaff). In like manner, in several Dredd Blog series we have delved into the constants of atoms in DNA and RNA genomes:
Genetic Constants In DNA and RNA, 2, 3, 4, 5
On The Origin Of A Genetic Constant, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14. 15
It's In The GenBank, 2, 3, 4, 5, 6, 7, 8, 9
The point of it all in one sense is that with this in mind a DNA or RNA sequence can be tested quite easily for accuracy.
These tests should primarily be utilized by researchers and scientists prior to submitting them to public databases such as GenBank:
"You've read or heard the phrase "don't blame the victim" I suppose.
So, let's not blame GenBank for what researchers put in it ..."
(It's In The GenBank - 9). So, keep that in mind when considering (Ten common issues with reference sequence databases and how to mitigate them).
The previous post in this series is here.
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