Wednesday, November 18, 2020

On The Origin Of The Home Of COVID-19 - 18

Some of my best friends are Germs

Dredd Blog has been pointing out the lack of understanding Western Civilization has of the "germosphere" (Microbial Languages: Rehabilitation of the Unseen).

This same lack of understanding applies to the world of viruses: "Tracing the origins of viruses is difficult ... studying their ancestry requires untangling it from the history of their hosts" (Where did viruses come from?).

Since viruses "can replicate only within a host cell" (The Origins of Viruses), we must ask and answer the question: "What is a host cell?" ("Host cell ... Definition ... noun, plural: host cells ... (1) A cell that harbors foreign molecules, viruses, or microorganisms. For example, a cell being host to a virus."... Biology Online).

Since "viruses ... cannot reproduce on their own" we must also ask and answer the question "why would a host reproduce them".

There are many reasons why hosts of viruses would reproduce the viruses within them:

 "Most consider viruses to be parasites, where infection benefits the virus, but decreases the fitness of the host. Now consider other scenarios, such as commensals and mutualists. A virus can be commensal, the virus benefits while host fitness is unaffected. A virus can be mutualistic, in which both organisms benefit and fitness increases. Such viral associations may provide advantages that promote evolution and biodiversity. Also consider that one virulent virus among a sea of non-virulent viruses does not equate to pathogenesis. Unless transmission and recovery rates are high, pathogenicity may be an evolutionarily poor strategy for viral survival. More likely, pathogenesis is the exception and not the rule, with more instances being discovered of viruses having cooperative roles with the host. There are many instances where an organism cannot exist without beneficial viruses ... endogenous retrovirus syncytin expression in the placenta of mammals allows for the development of the placental syncytium. This syncytial fusion creates a barrier for the placenta, which in part keeps the fetus from being rejected by the mother’s immune system. Viruses can also modulate the immune system and restore dysbiotic conditions ... It is becoming evident that viruses have the potential to be something more than parasites in a holobiont, which revises conceptions of how viruses impact host interactions."

(The Intra-Dependence of Viruses and the Holobiont, Grasis, JA, 2017). Equally interesting is what is inside the host that does the replication of mutualistic viruses:

Nucleobase/nucleotide comparisons

"The protein-based molecular motors rely on an energy-rich molecule known as adenosine triphosphate (ATP), which is basically a nucleotide having three phosphate molecules that play a vital role in its energetics, and make it an indispensable commodity of life. The machines described in this section, the F0-F1 ATPase, the kinesin, myosin, and dynein superfamily of protein molecular machines, and bacteria flagellar motors all depend, directly or indirectly, on ATP for their input energy."

(Molecular Machines, bold added). That "(ATP),which is basically a nucleotide" is found abundantly in the DNA/RNA sequences of viruses. 

Specifically, the particular molecular machine that does the work of microbe replication is the ribosome (The ribosome as a molecular machine).

That is why Dredd Blog has presented the argument in this series that SARS-CoV2 is generated by the injection of toxic chemicals / antibiotics into the food system by the "mass slaughtering of cows, pigs, and chickens industry", thereby killing beneficial microbes which host beneficial (mutualistic pre-SARS-CoV2) viruses within them (On The Origin Of The Home Of COVID-19, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17).

The next post in this series is here, the previous post in this series is here.




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