Thursday, July 23, 2020

On The Origin Of The Home Of COVID-19 - 12

Fig. 1 What if the 'V' is a symbiotic virus?
I. Background

In this series Dredd Blog has pointed out the "understudied" and "not well understood" aspects of "the home" of viruses in the sense of "the home" being "the host microbe" (see Fig. 1).

Strong circumstantial evidence has been provided to support the hypothesis.

As a result the industry that Dredd Blog hypothesizes as being the culprit has produced a frenzied media storm to divert the attention and the research.

The bulk of literature in the Commentariat insinuates by repetition that all viruses inhabit the zone outside of single-cell microbes, and have to break into (infect) single-cell microbes in order to be replicated.

In other words, the bias of the Commentariat often bends the scientific research to make it more 'palatable', so the fact of the majority of viruses being inside single cell microbes as symbionts (mutualist, commensal) is under-reported and/or misreported (A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology).

There are many examples.

First, notice the "Abstract" of a paper which indicates, concerning viruses, that we are not at war with a universal enemy out to get us:
"Much attention has focused on commensal bacteria in health and disease, but the role of commensal viruses is understudied. Although metagenomic analysis shows that the intestine of healthy humans and animals harbors various commensal viruses and the dysbiosis of these viruses can be associated with inflammatory diseases, there is still a lack of causal data and underlying mechanisms to understand the physiological role of commensal viruses in intestinal homeostasis. In the present study, we show that commensal viruses are essential for the homeostasis of intestinal intraepithelial lymphocytes ..."
(Nature, emphasis added). The commercial Commentariat influenced by advertising revenue, persists in making all viruses and bacteria out to be bad enemies ("the yellow peril", the "China virus").

That is not the complete picture, it is a cover up and/or a diversion, because it is not a true picture.

There is more substantial evidence for the Dredd Blog hypothesis:
"The coronavirus may have been lying dormant across the world until emerging under favourable environmental conditions, rather than originating in China, an expert has claimed.

Dr Tom Jefferson, from the Centre for Evidence-Based Medicine (CEBM) at Oxford University, has pointed to a string of recent discoveries of the virus’s presence around the world before it emerged in Asia as growing evidence of its true origin as a global organism that was waiting for favourable conditions to finally emerge.

Traces of COVID-19 have been found in sewage samples from Spain, Italy and Brazil which pre-date its discovery in China. A preprint study, which has not been peer reviewed, claims to have found the presence of SARS-CoV-2 genomes in a Barcelona sewage sample from 12 March 2019."
(The coronavirus may not have originated in China, says Oxford professor, emphasis added; cf. The biggest mystery: what it will take to trace the coronavirus source, Animal source of the coronavirus continues to elude scientists).

The SARS-CoV-2 origin is not really known because of the bias built into the system:
"The emergence of SARS-CoV-2 in late 2019 and its subsequent global spread has led to millions of infections and substantial morbidity and mortality. Coronavirus disease 2019 (COVID-19), the clinical disease caused by SARS-CoV-2 infection, can range from mild self-limiting disease to acute respiratory distress syndrome and death. The mechanisms underlying the spectrum of COVID-19 disease severity states, and the nature of protective immunity against COVID-19 currently remains unclear."
(Selective and cross-reaction). That paper assumes that the people they were testing (who had indications of some exposure to SARS-CoV-2, i.e. similar T-cell characteristics) had not been exposed.

That is a flawed assumption IMO (Italy’s sewage water shows SARS-CoV-2 present prior to reported outbreak in Wuhan, Coronavirus found in Paris sewage points to early warning system, How sewage could reveal true scale of coronavirus outbreak).

The hypothesis this series has been advancing is that any number of commensal viruses are inside single-cell microbes because that is their home (see Fig. 1).

When their single-celled home is invaded and destroyed by antibiotics or other toxins, the world of commensal viruses is upended, and they can then become pathogenic (kinda like PTSD for otherwise stable viruses).

The mechanism for this upsetting (dysbiosis) in the microbiome is the mass-production-of-food industry (i.e. the "mass slaughtering of cows, pigs, and chickens" industry).

Not content with selling the muscle and fat,  "the industry" exports offal to other countries where it is used as food for people and feed on fur bearing animal farms, etc. (On The Origin Of The Home Of COVID-19 - 11).

II. The Battlefield

So, Dredd Blog has focused on the mass-production-of-food industry as an integral part of the current COVID-19 pandemic.

There is scientific research supporting that hypothesis in recent published papers, for example from Nature magazine:
"Editorial Summary

Minor role for host genetics in shaping the microbiota

The composition of the human gut microbiome is determined by many factors. Eran Segal and colleagues performed an extensive statistical analysis of the largest metagenomics-sequenced human cohort so far to determine the contribution of host genotype to microbiome composition. Host genetics has only a minor influence on microbiome variability, which is more strongly associated with environmental factors such as diet. The authors propose a 'microbiome-association index' that describes the association of the microbiome with host phenotype. Combining this measurement with host genetic and environmental data improves the accuracy of predictions about several human metabolic traits, such as glucose and obesity traits."
...
"A wealth of evidence suggests that this incredibly diverse microbial community is regulated by host genetic factors, and more importantly, environmental and dietary factors (4–6)"."
(Environment dominates over host genetics in shaping human gut microbiota, Nature, emphasis added). The papers cited to in that Nature piece echo the science involved:
"Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds."
(Nature, 2018, emphasis added). This is common knowledge in the field of Epigenetics (On The Origin of Genieology, The Uncertain Gene - 11).

So, the mass food producers (using an army of antibiotics and other chemicals) wage war on the gut and other microbiota that engenders dysbiosis, then they sell the offal, which in turn drives the ill gotten profits of "the industry" (and some portion of the "health industry" as well).

III. Appendices

I am providing links to previous appendices which highlight virus comparisons involving different geographical locations as well as as highlighting different species.

The thing to notice is the ~99% and ~100% matches in SARS-CoV-2 DNA/RNA in those various countries and species.

Remember as you view them that the species have a similar diet to the humans (e.g. cows, pigs, and poultry) as indicated previously (On The Origin Of The Home Of COVID-19 - 10).


GenBase
Identity
Appendix
Location
MT276327Appendix A
MT276327Appendix B
MN997409 Appendix C
MN997409Appendix D

IV. Closing Comments

Think about it.

Think about the Epigenetic diet of offal which the minks and other animals were fed to "grow" them for their fur.

Think about the people and animals who have 99-100% matching SARS-CoV-2 DNA/RNA in them.

Think about their diet.

Do the humans eat beef, pork, chicken that come from the mass-produced meat, and do the animals eat the offal of the beef, swine, and poultry?

We know that the workers who handle and eat the meats have the same SARS-CoV-2 DNA/RNA in them.

Think about it.

Just sayin' ...

The previous post in this series is here.

3 comments:

  1. Since single celled microbes have survived about 101 million years in low-organic soils, why can't symbiotic viruses have survived in and/or on them? (link)

    ReplyDelete
  2. Records of wastewater (sewage) are kept (40 CFR Part 503)

    ReplyDelete
  3. "(1) Enteric viruses. ASTM Designation: D 4994-89, “Standard Practice for Recovery of Viruses From Wastewater Sludges”, 1992 Annual Book of ASTM Standards: Section 11 - Water and Environmental Technology, ASTM, 1916 Race Street, Philadelphia, PA 19103-1187." see link in my comment above

    ReplyDelete