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Monday, July 31, 2023

Quantum Biology - 22

Where da atoms at?

I. It's So Fundamental

This series covers a lot of ground (Quantum Biology, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21).

But let's remember for a moment that Quantum Biology is about the atomic quanta that are fundamental to DNA and RNA.

And of course DNA and RNA are fundamental to both life forms (e.g. cells) and also to non-life forms (e.g. viruses).

The fundamental "look and feel" of those fundamentals are as follows:

Atoms: (elements of relevant genomes)

"C" = Carbon
"H" = Hydrogen
"N" = Nitrogen
"O" = Oxygen

DNA (Total Atom Counts: "C19H21N15O4")

DNA Nucleotide Atom Counts:

"Adenine", "A", "ADE", "C5H5N5"
"Cytosine", "C", "CYT", "C4H5N3O1"
"Guanine", "G", "GUA", "C5H5N5O1"
"Thymine", "T", "THY", "C5H6N2O2"

RNA (Total Atom Counts: "C18H19N15O4")

RNA Nucleotide Atom Counts:

"Adenine", "A", "ADE", "C5H5N5"
"Cytosine", "C", "CYT", "C4H5N3O1"
"Guanine", "G", "GUA", "C5H5N5O1"
"Uracil", "U", "URA", "C4H4N2O2"

II. The Fingerprint Pattern of DNA

Today's five appendices detail the ~(32/35/25/6) fingerprint pattern of the DNA in life forms from human to bacteria (Appendix One, Two, Three, Four, and Five).

It is remarkable that such a fingerprint pattern exists in the genetic material of all entities that contain a 'genome'.

There are links to all of the genomes presented in the appendices so that readers can look up the GBFF and/or FASTA files in the GenBank.

III. How The Fingerprint Pattern Is Derived

First, select and download a FASTA version of a GenBank link.

Next, parse each nucleotide, one at a time, in from beginning to end.

For each nucleotide, add the atom counts for each atom type, and separately keep a total atom count of all atoms: 

Example: nucleotide 1 is 'A' which has 5 carbon, 5 hydrogen, 5 nitrogen, and 0 oxygen atoms; thus the total atoms type count would be 5+5+5+0 = 15 (total atoms); nucleotide 2 is 'C' which has 4 carbon, 5 hydrogen, 3 nitrogen, and 1 oxygen atom, thus the total type counts and  total atoms count  would now be (5+5+5+0 = 15) + (4+5+4+1 = 14) [15+14 = 29]; and so forth for each genome being processed; at the end divide each atom type's total by the total atom count; example 9 carbon atoms (5+4) divided by a 29 total atom count = 31.03%, 10 carbon atoms (5+5) divided by that 29 atom count = 34.48%, etc.; don't include 'N' characters in the count, i.e. count only 'A' 'C' 'G' 'T' and 'U' characters.

Caution, the fingerprint pattern is at maximum accuracy only when a complete genome sequence is used (all A,C,G and T nucleotides) as was done in the five appendices).

IV. Closing Comments

You may be wondering what this discovery can be used for.

Good question.

In a future post I will show how it can be used to detect chimera genomes so one doesn't use a chimera genome when only a sound genome is called for, or one does use a chimera genome when analyzing only chimera cases.

The previous post in this series is here.




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